Original model drawing by Chuck Jones, graphite on paper, (see below complete model sheet, upper left corner) of the Road Runner for the first Wile E. Coyote and Road Runner cartoon, "Fast  & Furry-ous" directed by Jones.  It beep-beeped into theaters on September 16, 1949.  

Rebecca Solnit writes in her essay, "From the Faraway to Some Nearby ACME" which appeared in Art Issues, December 1999: "The Road Runner and Wile E. Coyote is the apotheosis of the cartoon, paring down its myriad possible ingredients to a simple recipe: space, delicious mostly for its blankness and invitation to move, desire eternally unfulfilled, hope that springs eternal anyway, unshakeably one-dimensional personalities, infinitely abusable bodies, and a whole lot of action."